Aldesleukin

Brand name: Proleukin

C[HD]

Score C[HD] — Probable Hepatotoxin (at high doses)

This drug is probably linked to idiosyncratic liver injury, but has been reported uncommonly and no characteristic signature has been identified.

Fewer than 12 cases without a significant case series.

[HD] High dose only — Liver injury occurs at high doses (e.g. overdose). Risk is lower at normal therapeutic doses.
Primary class Antineoplastic
Secondary class Solid tumors, Lymphoma
FDA approval 1992