Allopurinol

Brand name: Zyloprim

DILI Likelihood

Score A — Well-Known Hepatotoxin

This drug is well known, well described, and well reported to cause either direct or idiosyncratic liver injury, with a characteristic signature.

More than 50 cases including case series have been described in the medical literature.

Classification

Primary class Rheumatologic

Secondary class Gout

FDA approval 1965