Nitisinone

Brand name: Orfadin

DILI Likelihood

Score E — Unlikely Hepatotoxin

Despite extensive use, there is no convincing evidence that this drug causes liver injury.

Single case reports may have been published, but they were largely unconvincing. The agent is not believed or is unlikely to cause liver injury.

Classification

Primary class Genetic

Secondary class Tyrosinemia

FDA approval 2002